Composition

• Escitalopram Oxalate — equivalent to escitalopram 10 mg: an SSRI antidepressant that affects serotonin signalling in the brain.
• Clonazepam — 0.5 mg: a benzodiazepine that enhances the effect of gamma-aminobutyric acid (GABA), a chemical messenger that helps calm nervous system activity.

Composition is based on the product details supplied. Check the original packaging for the exact label wording and complete product information.

Product Introduction

TANDRA ES-10 Tablets combine medicines with different actions. Escitalopram is commonly used to treat depression and certain anxiety-related conditions. Clonazepam may be prescribed for selected symptoms or conditions requiring short-term calming effects, depending on the clinician's assessment.

This combination is not suitable for everyone and requires medical supervision. Clonazepam can cause drowsiness and dependence, so the need for continued use should be reviewed regularly.

Uses of TANDRA ES-10 Tablets

• May be prescribed for selected patients with anxiety-related symptoms.
• May be used when a clinician determines that escitalopram treatment and short-term additional calming support are appropriate.
• Escitalopram may be prescribed for depression, panic disorder, generalised anxiety disorder and other approved indications, depending on clinical assessment.

These are general uses of the individual ingredients, not confirmation of every approved indication for this specific combination. Diagnosis and treatment decisions belong to a qualified prescriber.

Potential Benefits

• Escitalopram may help reduce symptoms of depression and certain anxiety disorders over time.
• Clonazepam can have a calming effect and may reduce selected symptoms in the short term when prescribed appropriately.
• The combination may be considered in selected treatment plans when the prescriber judges that the potential benefits outweigh the risks.

Response varies between individuals. Escitalopram may take several weeks to provide noticeable benefit, and clonazepam is not a substitute for longer-term treatment of the underlying condition.

Possible Side Effects

Possible side effects include sleepiness, dizziness, tiredness, nausea, headache, sweating, changes in sleep, bowel disturbances and sexual side effects. The combination may impair alertness, coordination and concentration.

Seek urgent medical help for severe breathing difficulty, inability to stay awake, fainting, a seizure, severe confusion, or symptoms such as fever, agitation, sweating and muscle stiffness that could indicate a serious reaction. New or worsening suicidal thoughts also require urgent professional support.

How to Use

• Take the tablet only as prescribed by a qualified healthcare professional.
• Follow the prescribed dose and timing; do not increase the dose or take extra tablets for sudden symptoms.
• Do not stop treatment suddenly. Escitalopram may cause discontinuation symptoms, and abrupt clonazepam withdrawal can cause serious symptoms, including seizures.
• If a dose is missed, follow the patient leaflet or ask your pharmacist or prescriber for advice. Do not double the next dose.
• Do not share this medicine with another person.

No individual dosing schedule is provided here. The prescriber must determine the appropriate regimen and review the ongoing need for clonazepam.

How It Works

Escitalopram

Escitalopram inhibits serotonin reuptake in the brain, increasing serotonin availability between nerve cells. This action can help improve symptoms of depression and certain anxiety disorders over time.

Clonazepam

Clonazepam enhances the activity of GABA, a neurotransmitter that reduces excessive nervous system activity. It can produce calming and sedative effects, but may also cause impaired coordination, tolerance and dependence.

Safety Advice

• Alcohol: Avoid alcohol. It can increase clonazepam-related sedation and may worsen impairment.
• Driving: Do not drive, ride a bike or operate machinery if sleepy, dizzy or less alert. Be particularly cautious when starting treatment or changing the dose.
• Other sedatives: Tell your doctor about opioid pain medicines, sleeping tablets, sedating antihistamines and other medicines that can slow the nervous system. Some combinations can dangerously suppress breathing.
• Dependence: Clonazepam can cause tolerance, dependence and withdrawal. Do not increase the dose yourself or stop it abruptly.
• Other medicines: Inform your clinician about all medicines and supplements, including other antidepressants, tramadol, medicines affecting heart rhythm, anticoagulants and St John's wort.
• Medical history: Tell your doctor about liver disease, breathing problems, sleep apnoea, seizure history, bipolar disorder, glaucoma or a history of substance dependence.
• Pregnancy and breastfeeding: Seek medical advice before use if pregnant, planning pregnancy or breastfeeding. Do not change treatment abruptly without professional guidance.
• Monitoring: Attend follow-up appointments, especially after starting treatment or changing doses.