Product Introduction

LETROKAND-2.5 Tablet reduces oestrogen production by inhibiting the aromatase enzyme, which converts certain hormones into oestrogens. Lowering oestrogen levels can help slow or control the growth of some hormone-sensitive breast cancers.

The medicine is generally used under specialist supervision. The reason for treatment, duration and monitoring depend on the patient's diagnosis, menopausal status, medical history and response to therapy.

Uses of LETROKAND-2.5 Tablet

• Hormone-sensitive breast cancer: Used in selected cases, especially in postmenopausal women, as adjuvant or other specialist-directed treatment.
• Reducing recurrence risk: May be prescribed after primary treatment for eligible patients with hormone receptor-positive breast cancer.
• Advanced breast cancer: May be used in selected cases where the cancer is hormone-dependent, according to the oncology treatment plan.
• Fertility treatment: Specialists sometimes use letrozole to induce ovulation in selected patients. This is a distinct treatment plan and requires fertility-specific guidance and monitoring.

Not all uses have the same regulatory status in every country. Use this prescription medicine only for the indication determined by the treating specialist.

Benefits / Potential Benefits

• Reduces oestrogen production in the body.
• Can help control the growth of certain hormone-sensitive breast cancers.
• May reduce the risk of breast cancer recurrence in eligible patients when used as part of an appropriate treatment plan.
• In selected fertility cases, may help stimulate ovulation under specialist supervision.

The expected benefit depends on the diagnosis, treatment setting and individual response. Letrozole is not suitable for every type of breast cancer or every fertility concern.

Possible Side Effects

Possible side effects of letrozole include:

• Hot flushes and increased sweating.
• Joint pain, muscle discomfort or bone pain.
• Fatigue, headache or dizziness.
• Nausea or other digestive discomfort.
• Increased cholesterol levels.
• Reduced bone mineral density with possible increased risk of osteoporosis or fractures during longer-term treatment.

How to Use LETROKAND-2.5 Tablet

• Take the tablet only as prescribed by your oncologist, gynaecologist or other qualified specialist.
• Follow the prescribed schedule and treatment duration. Instructions can differ between cancer treatment and fertility treatment.
• Swallow the tablet with water according to the product instructions. Letrozole tablets are commonly taken with or without food.
• If you miss a dose, follow the patient leaflet or ask your pharmacist. Do not take a double dose to make up for a missed tablet.
• Do not stop, restart or change the dose without discussing it with your prescriber.
• Attend recommended follow-up appointments and laboratory or imaging assessments.

No individualized dosing schedule is provided here. The correct regimen depends on the clinical indication and the specialist's treatment plan.

How It Works

Letrozole inhibits aromatase, an enzyme involved in the production of oestrogen. This reduces circulating oestrogen levels and the availability of oestrogen that can stimulate certain hormone-sensitive breast cancer cells.

In selected fertility treatment plans, the temporary reduction in oestrogen can influence the body's hormonal feedback mechanisms and support follicle development and ovulation. This use requires careful timing and appropriate clinical monitoring.

Safety Advice

• Pregnancy: Letrozole can harm a developing fetus and should not be used during pregnancy. If pregnancy is possible, contact your prescriber before taking it. Fertility treatment requires a specialist-directed plan to determine timing and pregnancy status.
• Breastfeeding: Discuss breastfeeding with your specialist before using letrozole.
• Bone health: Long-term treatment can reduce bone mineral density. Your clinician may recommend bone-health assessment, exercise, dietary measures or additional treatment when appropriate.
• Cholesterol: Letrozole may increase cholesterol levels. Follow your clinician's recommendations for monitoring.
• Liver or kidney problems: Inform your doctor about any significant liver or kidney condition before treatment.
• Other medicines: Share a complete list of prescription medicines, non-prescription products and supplements with your healthcare professional.
• Dizziness or fatigue: Avoid driving or operating machinery if you feel dizzy, unusually tired or have blurred vision.
• Fertility treatment: Attend recommended monitoring appointments. Seek prompt advice for significant abdominal pain or swelling during ovulation induction.

Quick Tips

• Use letrozole only for the indication and schedule prescribed by your specialist.
• Keep a record of appointments, test results and any side effects.
• Discuss bone health and cholesterol monitoring if you are receiving long-term treatment.
• Do not take additional hormone-related medicines or fertility medicines without professional advice.
• Report persistent joint pain, unusual fatigue or other troublesome symptoms to your clinician.
• Store the tablets according to the package instructions and keep them out of children's reach.
• Check the expiry date and do not use tablets from damaged packaging.