Composition

• Atorvastatin Calcium — equivalent to atorvastatin 10 mg: a statin that reduces cholesterol production in the liver and helps lower LDL cholesterol.
• Fenofibrate — 160 mg: a fibrate that helps reduce triglyceride levels and may improve other blood lipid measurements.

Composition is based on the product details supplied. Refer to the original packaging for complete product information.

Product Introduction

TGAKAND Tablets are intended for cholesterol and triglyceride management when both active ingredients are considered necessary. The two medicines work through different mechanisms to improve blood lipid levels.

Combining a statin with fenofibrate can increase the risk of muscle-related adverse effects and requires medical supervision. This combination is not suitable for everyone, particularly people with certain liver, kidney or gallbladder conditions.

Uses of TGAKAND Tablets

• Management of selected mixed lipid disorders involving elevated cholesterol and triglycerides.
• Lowering LDL cholesterol as part of a prescribed lipid-management plan.
• Reducing elevated triglycerides in appropriate patients.
• Supporting long-term management of abnormal blood lipid levels alongside diet and lifestyle measures.

The combination should be used only when a clinician considers both ingredients necessary after reviewing lipid results, medical history and other treatments.

Potential Benefits

• Atorvastatin helps lower LDL cholesterol.
• Fenofibrate helps lower triglycerides.
• The combination may improve more than one abnormal lipid measurement in selected patients.
• Improved lipid levels can form part of a broader plan to manage cardiovascular risk.

Results vary by patient. Improvement in laboratory values does not guarantee prevention of a cardiovascular event, and the benefit of combination therapy should be assessed by the prescriber.

Possible Side Effects

Possible side effects include digestive discomfort, nausea, diarrhoea, headache and changes in liver enzyme test results.

Important muscle warning: Using atorvastatin with fenofibrate increases the risk of muscle injury, including a rare but serious condition called rhabdomyolysis. Seek urgent medical attention for unexplained muscle pain, tenderness or weakness, especially if accompanied by fever, severe tiredness or dark-coloured urine.

Persistent abdominal pain, yellowing of the skin or eyes, or unusual changes in urination also require prompt medical assessment.

How to Use

• Take the tablet only as prescribed by your healthcare professional.
• Follow the product leaflet or pharmacist's instructions about timing and food.
• Do not change the dose or stop treatment without consulting your prescriber.
• If you miss a dose, follow the patient leaflet or ask your pharmacist for advice. Do not take a double dose to compensate.
• Continue recommended dietary and lifestyle measures alongside treatment.

No individual dosing schedule is provided here. The prescriber determines the appropriate regimen based on your condition and monitoring results.

How It Works

Atorvastatin

Atorvastatin inhibits HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. This helps lower LDL cholesterol in the bloodstream.

Fenofibrate

Fenofibrate acts on pathways involved in lipid metabolism and helps the body process and clear triglyceride-rich particles from the blood.

Safety Advice

• Kidney health: Tell your doctor if you have kidney disease. Fenofibrate may be unsuitable or require a different dose depending on kidney function.
• Liver health: Inform your clinician about liver disease or previous abnormal liver tests. Blood tests may be required during treatment.
• Gallbladder: Tell your doctor if you have gallstones or gallbladder disease.
• Muscle symptoms: Report unexplained muscle pain, tenderness or weakness promptly, particularly because these medicines are used together.
• Other medicines: Tell your healthcare professional about all medicines and supplements, especially anticoagulants such as warfarin, colchicine, ciclosporin and other cholesterol-lowering medicines.
• Pregnancy and breastfeeding: Seek medical advice before use. Atorvastatin is generally avoided during pregnancy and breastfeeding; the prescriber should review treatment if pregnancy occurs or is planned.
• Alcohol: Discuss alcohol use with your clinician, particularly if you drink heavily or have liver problems.
• Monitoring: Attend recommended lipid, liver-function and kidney-function tests.