3. Uses of Medicine

Depending on the approved product information and the clinical situation, misoprostol may be used for specific purposes such as:

• Reducing the risk of certain NSAID-associated gastric ulcers in selected patients when prescribed for that indication.
• Cervical preparation before selected medical procedures.
• Specialist-directed management of certain obstetric or gynaecological conditions, according to applicable clinical guidelines.

4. Benefits / Potential Benefits

When prescribed for an appropriate indication, misoprostol may:

• Help protect the stomach lining against certain NSAID-associated ulcers.
• Soften the cervix when cervical preparation is clinically indicated.
• Produce controlled uterine contractions when used within a suitable specialist-directed treatment protocol.

Potential benefits depend on the medical indication, the patient's condition and appropriate clinical supervision. Misoprostol is not suitable for every patient or every situation, and its effects can be serious if it is used incorrectly.

5. Possible Side Effects

Possible side effects can vary according to the indication and route of administration. They may include:

• Abdominal pain or cramping.
• Diarrhoea.
• Nausea or vomiting.
• Headache, dizziness or chills.
• Vaginal bleeding when used in an obstetric or gynaecological setting.
• Fever or temporary shivering in some treatment settings.

Serious warning signs

• Very heavy bleeding, fainting or severe weakness.
• Severe or persistent abdominal pain.
• Difficulty breathing, facial swelling or another sign of a serious allergic reaction.
• Persistent fever or feeling seriously unwell after treatment.

Seek urgent medical attention for severe symptoms. In obstetric or gynaecological use, the treating team should explain which symptoms require emergency assessment.

6. How to Use

• Use MISOKAND-200 only when prescribed for a specific medical indication.
• Follow the exact clinician-provided instructions for the intended indication and route.
• Do not decide the dose, timing, route or number of tablets yourself; these differ substantially between uses.
• Do not share the medicine with another person.
• If prescribed for ulcer prevention, follow the clinician's instructions and discuss pregnancy-related precautions before starting.
• If used in obstetric or gynaecological care, follow the specialist's treatment and follow-up plan and ensure you know how to access urgent care.

7. How It Works

Misoprostol is a synthetic analogue of prostaglandin E1. It acts on prostaglandin receptors and produces effects in different tissues.

Effects on the stomach

Misoprostol helps protect the stomach lining by reducing gastric acid secretion and supporting protective mucus and bicarbonate production.

Effects on the cervix and uterus

Misoprostol can soften and open the cervix and stimulate uterine contractions. These effects are used in certain specialist-directed obstetric and gynaecological settings and are also the reason the medicine can be dangerous during pregnancy when used for an unrelated indication.

8. Safety Advice

• Pregnancy: Misoprostol can cause miscarriage, premature birth, birth defects or uterine rupture. If it has been prescribed for ulcer prevention, tell your clinician if you are pregnant, may be pregnant or are planning pregnancy.
• Previous uterine surgery: A previous caesarean delivery or other uterine surgery can affect the risk profile in obstetric use. The specialist must assess this history.
• Bleeding or uterine conditions: Tell your clinician about unexplained vaginal bleeding, blood-clotting problems or relevant gynaecological conditions.
• Stomach or bowel conditions: Discuss significant diarrhoea, inflammatory bowel conditions or dehydration with your healthcare professional.
• Other medicines: Provide a complete list of medicines and supplements, especially NSAIDs and medicines that may affect bleeding or gastrointestinal symptoms.
• Breastfeeding: Ask your healthcare professional for advice based on the reason for treatment and your individual circumstances.
• Monitoring: Follow any required examination, monitoring or follow-up plan associated with the prescribed indication.
• Storage: Keep the medicine in its original packaging and follow the manufacturer's storage instructions. Keep it away from children and anyone for whom it was not prescribed.

9. Quick Tips

• Confirm the intended medical use before taking the medicine.
• Use only the dose, route and timing specified by the treating clinician.
• Do not use misoprostol for self-directed pregnancy-related treatment.
• Tell your clinician about pregnancy possibility and any history of uterine surgery.
• Know the warning signs that require urgent medical care.
• Attend all recommended follow-up appointments.
• Do not share the medicine or use someone else's prescription.
• Store it safely and follow the package instructions.